Gammaglutamyltransferase (GGT) is one of the most sensitive markers of cholestatic liver syndrome, alcoholic and toxic liver injury, and liver metastases, and its elevation can become apparent early in the disease. GGT rises in 90% of patients with liver disease. This test indicates the presence of a pathology, but does not indicate the cause of the lesion. An increase in the index can be linked to liver diseases such as hepatitis and cirrhosis, as well as other conditions in the body such as heart failure, diabetes mellitus, inflammation of the pancreas, and the use of alcohol or medicines. GGT activity is elevated in infectious mononucleosis, myocardial infarction, renal failure and chronic obstructive pulmonary disease. It can determine the risk of alcoholism in men (but not in women) and assess the effectiveness of treatment for alcoholics. The recommended blood level is 9-40 U/l. Neonatal GGT activity is higher than in adults.

Gammaglutamyltransferase (GGT) is one of the most sensitive indicators of cholestatic liver injury. Single and continuous administration of alcohol or hepatotoxic substances (medications) can cause an increase in serum GGT activity. It is important to take into account the age and sex of the patient when assessing the GGT laboratory indicator. Shortly after birth, GGT activity is higher than it is in an adult. GGT activity further increases until about 6 months of life. GGT activity then drops sharply and reaches a minimum around 7 years of age. During puberty, its activity increases again. Although GGT is an enzyme found in many organs, it is only in pathologies of the liver, biliary tract and pancreas that its concentration in the blood changes. GGT is indispensable for assessing the course of hepatitis that does not manifest as jaundice. Elevated levels of GGT are observed in patients with alcoholic cirrhosis, and in the serum of most heavy drinkers, GGT is important for alcoholism, for the detection of alcoholic liver damage, and for the monitoring of alcohol abstinence.

Recommendations:

• It is recommended to be carried out as a prophylactic measure once a year, and periodically as prescribed by your doctor for the diagnosis of diseases and monitoring of treatment.
• The results are influenced by the medications taken and diet (supplements taken).
• The test collection requires a fasting arrival at 12:00.

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