The uric acid index is used to diagnose gout and hyperuricaemia and to monitor the course of treatment. Elevated uric acid levels in the blood do not necessarily indicate gout. Only about 10-15% of hyperuricaemia cases are directly related to gout. Very high bilirubin concentrations can interfere with the correct determination of uric acid levels. Its concentration in the blood depends on purine nucleotide metabolism. Uric acid, the increase in its concentration in the blood, is mainly due to an excess of protein (gout) or tissue collapse (leukaemia, antitumour treatment, tissue necrosis). The most common cause of hyperuricaemia is kidney damage. Excess uric acid in the blood is often itself a cause of kidney damage. There are three such pathologies where hyperuricaemia causes kidney damage: 1) acute uric acid nephropathy; 2) kidney stones; 3) chronic urate nephropathy.
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