Mycoplasma pneumoniae IgM
For the diagnosis of acute infection caused by Mycoplasma pneumoniae. Mycoplasma pneumoniae serum primary M-class antibody (IgM) titres rise after approximately 2 weeks. from the time of infection or even later, and disappears within about a year.
Depending on the person’s immune system, the serum titre of Mycoplasma pneumoniae primary M-class antibodies (IgM) rises after about 2 weeks. from the time of infection or even later, and disappears within about a year. In the case of reinfection, there may be little or no IgM response (only G-class antibodies are produced – IgG).
Mycoplasma pneumoniae IgG titre rises later, after 3-4 weeks. In acute infections, antibody levels rise 4-5 times above normal. After recovery, IgG levels drop, but the antibodies can continue to circulate in the serum for several years. To confirm mycoplasma infection, it is necessary to test paired sera, i.e. repeat the test after 2-3 weeks. and monitor antibody dynamics. In addition, a CRB test should be performed (CRB sometimes reacts to acute mycoplasma infection).
Chlamydia pneumoniae IgM and IgG
In primary Chlamydia pneumoniae infection, the immune response is relatively slow, with IgM appearing after 2-3 weeks and IgG after 4-6 weeks. Although IgM levels decrease after a few months, low titres are found for up to a year. In autoimmune diseases, false-positive Chlamydia pneumoniae IgM titres are due to elevated rheumatoid factor.
In the case of reinfection, usually only IgG is produced and the increase is faster than in the initial infection. Occasionally, slightly elevated IgG titres of Chlamydia pneumoniae can also be detected in healthy individuals with no evidence of respiratory tract infection.
Due to the slow immune response and the controversial antibody profile, Chlamydia pneumoniae infection is best detected directly by molecular PCR of a throat swab.
In primary Chlamydia pneumoniae infection, the immune response is relatively slow, with IgM appearing after 2-3 weeks and IgG after 4-6 weeks.
In primary Mycoplasma pneumoniae infection, the serum IgM titre rises after about 2 weeks, while the IgG titre rises 3-4 weeks after infection or even later.
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